6H9B

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

Summary for 6H9B

Entry DOI	10.2210/pdb6h9b/pdb
Descriptor	Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total)
Functional Keywords	cytoskeleton, cell division, intracellular transport, transport protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	5
Total formula weight	214031.09
Authors	Varela, P.F.,Gigant, B. (deposition date: 2018-08-03, release date: 2018-12-19, Last modification date: 2024-01-17)
Primary citation	Naret, T.,Khelifi, I.,Provot, O.,Bignon, J.,Levaique, H.,Dubois, J.,Souce, M.,Kasselouri, A.,Deroussent, A.,Paci, A.,Varela, P.F.,Gigant, B.,Alami, M.,Hamze, A. 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. J. Med. Chem., 62:1902-1916, 2019 Cited by PubMed: 30525602 DOI: 10.1021/acs.jmedchem.8b01386 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation