6H9B

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

6H9B の概要

• エントリーDOI: 10.2210/pdb6h9b/pdb
• 分子名称: Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total)
• 機能のキーワード: cytoskeleton, cell division, intracellular transport, transport protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 214031.09

構造登録者

Varela, P.F.,Gigant, B. (登録日: 2018-08-03, 公開日: 2018-12-19, 最終更新日: 2024-01-17)

• 主引用文献: Naret, T.,Khelifi, I.,Provot, O.,Bignon, J.,Levaique, H.,Dubois, J.,Souce, M.,Kasselouri, A.,Deroussent, A.,Paci, A.,Varela, P.F.,Gigant, B.,Alami, M.,Hamze, A.; 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.; J. Med. Chem., 62:1902-1916, 2019; PubMed: 30525602; DOI: 10.1021/acs.jmedchem.8b01386

実験手法

X-RAY DIFFRACTION (2.75 Å)