6H8R

CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND 2

6H8R の概要

• エントリーDOI: 10.2210/pdb6h8r/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 5, SULFATE ION, 3-[(2~{S})-2-azanylpropyl]-5-(trifluoromethyl)phenol, ... (4 entities in total)
• 機能のキーワード: protein phosphatase, ptn5, step, allosteric modulator, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35520.11

構造登録者

Hoerer, S.,Fiegen, D.,Schnapp, G. (登録日: 2018-08-03, 公開日: 2018-09-26, 最終更新日: 2024-01-17)

• 主引用文献: Tautermann, C.S.,Binder, F.,Buttner, F.H.,Eickmeier, C.,Fiegen, D.,Gross, U.,Grundl, M.A.,Heilker, R.,Hobson, S.,Hoerer, S.,Luippold, A.,Mack, V.,Montel, F.,Peters, S.,Bhattacharya, S.,Vaidehi, N.,Schnapp, G.,Thamm, S.,Zeeb, M.; Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.; J. Med. Chem., 62:306-316, 2019; PubMed: 30207464; DOI: 10.1021/acs.jmedchem.8b00857

実験手法

X-RAY DIFFRACTION (1.66 Å)