6H5W
Crystal structure of human Angiotensin-1 converting enzyme C-domain in complex with Omapatrilat.
Summary for 6H5W
| Entry DOI | 10.2210/pdb6h5w/pdb |
| Descriptor | Angiotensin-converting enzyme, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
| Functional Keywords | angiotensin-1 converting enzyme, ace inhibitor, omapatrilat, vasopeptidase inhibitor, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 71725.56 |
| Authors | Cozier, G.E.,Acharya, K.R. (deposition date: 2018-07-25, release date: 2018-11-07, Last modification date: 2024-01-17) |
| Primary citation | Cozier, G.E.,Arendse, L.B.,Schwager, S.L.,Sturrock, E.D.,Acharya, K.R. Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design. J. Med. Chem., 61:10141-10154, 2018 Cited by PubMed: 30372620DOI: 10.1021/acs.jmedchem.8b01309 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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