6H5O

Crystal structure of PBP2a from MRSA in complex with piperacillin at active site.

Summary for 6H5O

• Entry DOI: 10.2210/pdb6h5o/pdb
• Descriptor: Penicillin binding protein 2 prime, Piperacillin (Open Form), CADMIUM ION, ... (4 entities in total)
• Functional Keywords: penicillin binding protein, hydrolase
• Biological source: Staphylococcus aureus (strain Mu50 / ATCC 700699)
• Total number of polymer chains: 2
• Total formula weight: 148624.15

Authors

Batuecas, M.T.,Martinez-Caballero, S.,Hermoso, J.A. (deposition date: 2018-07-25, release date: 2019-08-14, Last modification date: 2024-01-17)

• Primary citation: Janardhanan, J.,Bouley, R.,Martinez-Caballero, S.,Peng, Z.,Batuecas-Mordillo, M.,Meisel, J.E.,Ding, D.,Schroeder, V.A.,Wolter, W.R.,Mahasenan, K.V.,Hermoso, J.A.,Mobashery, S.,Chang, M.; The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.; Antimicrob.Agents Chemother., 63:-, 2019; PubMed: 30858202; DOI: 10.1128/AAC.02637-18

Experimental method

X-RAY DIFFRACTION (2.82 Å)