6H5J

Crystal structure of DHQ1 from Salmonella typhi covalently modified by ligand 4

6H5J の概要

• エントリーDOI: 10.2210/pdb6h5j/pdb
• 分子名称: 3-dehydroquinate dehydratase, (3~{R})-3,4,5-tris(hydroxyl)cyclohexane-1-carboxylic acid (3 entities in total)
• 機能のキーワード: lyase activity, chorismate biosynthetic process, 3-dehydroquinase, covalent inhibitor, lyase
• 由来する生物種: Salmonella typhi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27857.16

構造登録者

Otero, J.M.,Maneiro, M.,Lence, E.,Sanz-Gaitero, M.,Thompson, P.,Hawkins, A.R.,Gonzalez-Bello, C.,van Raaij, M.J. (登録日: 2018-07-24, 公開日: 2019-07-24, 最終更新日: 2019-10-09)

• 主引用文献: Maneiro, M.,Lence, E.,Sanz-Gaitero, M.,Otero, J.M.,van Raaij, M.J.,Thompson, P.,Hawkins, A.R.,Gonzalez-Bello, C.; Hydroxylammonium Derivatives for Selective Active-site Lysine Modification in the Anti-virulence Bacterial Target DHQ1 Enzyme.; Org Chem Front, 6:3127-3135, 2019; DOI: 10.1039/c9qo00453j

実験手法

X-RAY DIFFRACTION (1.4 Å)