6H54
CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008
Summary for 6H54
Entry DOI | 10.2210/pdb6h54/pdb |
Related | 4fl9 |
Descriptor | Heat shock cognate 71 kDa protein, trimethylamine oxide, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, ... (6 entities in total) |
Functional Keywords | chaperone, hsc70, vernalis inhibitor |
Biological source | Bos taurus (cattle) |
Total number of polymer chains | 1 |
Total formula weight | 61940.78 |
Authors | Plank, C.,Zehe, M.,Grimm, C.,Sotriffer, C. (deposition date: 2018-07-23, release date: 2019-08-14, Last modification date: 2024-02-14) |
Primary citation | Zehe, M.,Kehrein, J.,Schollmayer, C.,Plank, C.,Kovacs, H.,Merino Asumendi, E.,Holzgrabe, U.,Grimm, C.,Sotriffer, C. Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024 Cited by PubMed: 38317495DOI: 10.1021/acschembio.3c00589 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
Download full validation report