6H46
Human KRAS in complex with darpin K13
Summary for 6H46
Entry DOI | 10.2210/pdb6h46/pdb |
Descriptor | GTPase KRas, darpin K13, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | gtp-ase, darpin, kras signalling, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 36676.03 |
Authors | Debreczeni, J.E.,Bery, N.,Legg, S.,Breed, J.,Embrey, K.,Stubbs, C.,Kolasinska-Zwierz, P.,Barrett, N.,Marwood, R.,Watson, J.,Tart, J.,Overman, R.,Miller, A.,Phillips, C.,Minter, R.,Rabbitts, T.H. (deposition date: 2018-07-20, release date: 2019-04-24, Last modification date: 2024-05-15) |
Primary citation | Bery, N.,Legg, S.,Debreczeni, J.,Breed, J.,Embrey, K.,Stubbs, C.,Kolasinska-Zwierz, P.,Barrett, N.,Marwood, R.,Watson, J.,Tart, J.,Overman, R.,Miller, A.,Phillips, C.,Minter, R.,Rabbitts, T.H. KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe. Nat Commun, 10:2607-2607, 2019 Cited by PubMed: 31197133DOI: 10.1038/s41467-019-10419-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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