6H23

Crystal structure of the hClpP Y118A mutant with an activating small molecule

Summary for 6H23

• Entry DOI: 10.2210/pdb6h23/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-[(2-chloranyl-4-fluoranyl-phenyl)methyl]-1,3,4-oxadiazole-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protease, small molecule, 14mer, serine protease, oligomerization, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 14
• Total formula weight: 357664.49

Authors

Kick, L.M.,Sieber, S.A.,Schneider, S. (deposition date: 2018-07-13, release date: 2018-08-29, Last modification date: 2019-04-03)

• Primary citation: Stahl, M.,Korotkov, V.S.,Balogh, D.,Kick, L.M.,Gersch, M.,Pahl, A.,Kielkowski, P.,Richter, K.,Schneider, S.,Sieber, S.A.; Selective Activation of Human Caseinolytic Protease P (ClpP).; Angew. Chem. Int. Ed. Engl., 57:14602-14607, 2018; PubMed: 30129683; DOI: 10.1002/anie.201808189

Experimental method

X-RAY DIFFRACTION (3.089 Å)