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6H1H

Crystal structure of human Pirin in complex with compound 7 (PLX4720)

Summary for 6H1H
Entry DOI10.2210/pdb6h1h/pdb
DescriptorPirin, FE (III) ION, [3-azanyl-2,6-bis(fluoranyl)phenyl]-(5-chloranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)methanone, ... (6 entities in total)
Functional Keywordstranscriptional coregulator, quercetin 2, 3-dioxygenase, inhibitor, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight33205.61
Authors
Ali, S.,Le Bihan, Y.V.,van Montfort, R.L.M. (deposition date: 2018-07-11, release date: 2018-11-28, Last modification date: 2024-01-17)
Primary citationMeyers, J.,Chessum, N.E.A.,Ali, S.,Mok, N.Y.,Wilding, B.,Pasqua, A.E.,Rowlands, M.,Tucker, M.J.,Evans, L.E.,Rye, C.S.,O'Fee, L.,Le Bihan, Y.V.,Burke, R.,Carter, M.,Workman, P.,Blagg, J.,Brown, N.,van Montfort, R.L.M.,Jones, K.,Cheeseman, M.D.
Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett, 9:1199-1204, 2018
Cited by
PubMed: 30613326
DOI: 10.1021/acsmedchemlett.8b00364
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.54 Å)
Structure validation

217705

數據於2024-03-27公開中

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