6H1H

Crystal structure of human Pirin in complex with compound 7 (PLX4720)

6H1H の概要

• エントリーDOI: 10.2210/pdb6h1h/pdb
• 分子名称: Pirin, FE (III) ION, [3-azanyl-2,6-bis(fluoranyl)phenyl]-(5-chloranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)methanone, ... (6 entities in total)
• 機能のキーワード: transcriptional coregulator, quercetin 2, 3-dioxygenase, inhibitor, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33205.61

構造登録者

Ali, S.,Le Bihan, Y.V.,van Montfort, R.L.M. (登録日: 2018-07-11, 公開日: 2018-11-28, 最終更新日: 2024-01-17)

• 主引用文献: Meyers, J.,Chessum, N.E.A.,Ali, S.,Mok, N.Y.,Wilding, B.,Pasqua, A.E.,Rowlands, M.,Tucker, M.J.,Evans, L.E.,Rye, C.S.,O'Fee, L.,Le Bihan, Y.V.,Burke, R.,Carter, M.,Workman, P.,Blagg, J.,Brown, N.,van Montfort, R.L.M.,Jones, K.,Cheeseman, M.D.; Privileged Structures and Polypharmacology within and between Protein Families.; ACS Med Chem Lett, 9:1199-1204, 2018; PubMed: 30613326; DOI: 10.1021/acsmedchemlett.8b00364

実験手法

X-RAY DIFFRACTION (1.54 Å)