6H15

Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10

Summary for 6H15

Entry DOI	10.2210/pdb6h15/pdb
Descriptor	Low-density lipoprotein receptor-related protein 6, VHH L-P2-B10, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	inhibitor, complex, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	171064.11
Authors	Gros, P.,van Scherpenzeel, R.C. (deposition date: 2018-07-11, release date: 2019-01-30, Last modification date: 2024-01-17)
Primary citation	Fenderico, N.,van Scherpenzeel, R.C.,Goldflam, M.,Proverbio, D.,Jordens, I.,Kralj, T.,Stryeck, S.,Bass, T.Z.,Hermans, G.,Ullman, C.,Aastrup, T.,Gros, P.,Maurice, M.M. Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells. Nat Commun, 10:365-365, 2019 Cited by PubMed: 30664649 DOI: 10.1038/s41467-018-08172-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation