6H15

Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10

Summary for 6H15

DescriptorLow-density lipoprotein receptor-related protein 6, VHH L-P2-B10, N-ACETYL-D-GLUCOSAMINE, ... (7 entities in total)
Functional Keywordsinhibitor, complex, signaling protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains4
Total molecular weight171226.25
Authors
Gros, P.,van Scherpenzeel, R.C. (deposition date: 2018-07-11, release date: 2019-01-30)
Primary citation
Fenderico, N.,van Scherpenzeel, R.C.,Goldflam, M.,Proverbio, D.,Jordens, I.,Kralj, T.,Stryeck, S.,Bass, T.Z.,Hermans, G.,Ullman, C.,Aastrup, T.,Gros, P.,Maurice, M.M.
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10:365-365, 2019
PubMed: 30664649 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-08172-z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24740 1.1% 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report