6H0U
Glycogen synthase kinase-3 beta (GSK3) complex with a covalent [1,2,4]triazolo[1,5-a][1,3,5]triazine inhibitor
Summary for 6H0U
Entry DOI | 10.2210/pdb6h0u/pdb |
Descriptor | Glycogen synthase kinase-3 beta, (2~{R})-3-[7-azanyl-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl]-2-cyano-propanamide, MALONATE ION, ... (7 entities in total) |
Functional Keywords | protein kinase, gsk3beta-covalent inhibitor complex, parkinson disease, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 94733.37 |
Authors | Marcovich, I.,Demitri, N.,De Zorzi, R.,Storici, P. (deposition date: 2018-07-10, release date: 2019-05-15, Last modification date: 2024-01-17) |
Primary citation | Redenti, S.,Marcovich, I.,De Vita, T.,Perez, C.,De Zorzi, R.,Demitri, N.,Perez, D.I.,Bottegoni, G.,Bisignano, P.,Bissaro, M.,Moro, S.,Martinez, A.,Storici, P.,Spalluto, G.,Cavalli, A.,Federico, S. A Triazolotriazine-Based Dual GSK-3 beta /CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. Chemmedchem, 14:310-314, 2019 Cited by PubMed: 30548443DOI: 10.1002/cmdc.201800778 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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