6H0A

Serum paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations

6H0A の概要

• エントリーDOI: 10.2210/pdb6h0a/pdb
• 分子名称: Serum Paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations, CALCIUM ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
• 機能のキーワード: beta-propeller, lactonase, hdl, organophosphate-hydrolase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40599.97

構造登録者

Ben-David, M.,Sussman, J.L.,Tawfik, D.S. (登録日: 2018-07-07, 公開日: 2019-07-17, 最終更新日: 2020-04-08)

• 主引用文献: Ben-David, M.,Soskine, M.,Dubovetskyi, A.,Cherukuri, K.P.,Dym, O.,Sussman, J.L.,Liao, Q.,Szeler, K.,Kamerlin, S.C.L.,Tawfik, D.S.; Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.; Mol.Biol.Evol., 37:1133-1147, 2020; PubMed: 31873734; DOI: 10.1093/molbev/msz298

実験手法

X-RAY DIFFRACTION (2.1 Å)