6H04

Closed conformation of the Membrane Attack Complex

Summary for 6H04

Related6H03
EMDB information0106 0107 0109 0110 0111 0112 0113
DescriptorComplement component C9, Complement C5,Complement C5, Complement component C8 beta chain, ... (8 entities in total)
Functional Keywordsc5b9, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains24
Total molecular weight1630616.64
Authors
Menny, A.,Serna, M.,Boyd, C.M.,Gardner, S.,Joseph, A.P.,Topf, M.,Bubeck, D. (deposition date: 2018-07-06, release date: 2018-12-19, Last modification date: 2018-12-26)
Primary citation
Menny, A.,Serna, M.,Boyd, C.M.,Gardner, S.,Joseph, A.P.,Morgan, B.P.,Topf, M.,Brooks, N.J.,Bubeck, D.
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9:5316-5316, 2018
PubMed: 30552328 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-07653-5
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (5.6 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers11 0.0% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6h04
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Molmil generated image of 6h04
rotated about x axis by 90°
Molmil generated image of 6h04
rotated about y axis by 90°