6GXE
Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14
Summary for 6GXE
Entry DOI | 10.2210/pdb6gxe/pdb |
Related | 6GXB |
Descriptor | Carbonic anhydrase 2, ZINC ION, 3-[2-[2-[2-[2-(aminomethyloxy)ethoxy]ethoxy]ethoxy]ethoxy]-~{N}-[4-[4-[(4-sulfamoylphenyl)carbamoylamino]phenoxy]butyl]propanamide, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, caii mutant to caix mimic, ca inhibitor, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 30299.53 |
Authors | Brynda, J.,Rezacova, P.,Pospisilova, K. (deposition date: 2018-06-27, release date: 2019-05-08, Last modification date: 2024-05-15) |
Primary citation | Pospisilova, K.,Knedlik, T.,Sacha, P.,Kostka, L.,Schimer, J.,Brynda, J.,Kral, V.,Cigler, P.,Navratil, V.,Etrych, T.,Subr, V.,Kugler, M.,Fabry, M.,Rezacova, P.,Konvalinka, J. Inhibitor-Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms Acs Omega, 2019 Cited by DOI: 10.1021/acsomega.9b00596PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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