6GWN

Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)

6GWN の概要

• エントリーDOI: 10.2210/pdb6gwn/pdb
• 分子名称: Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64, ... (4 entities in total)
• 機能のキーワード: plasminogen activator inhibitor-1, pai-1, pai-1-w175f, serpin, protease inhibitor, serine protease inhibitor, nanobody, antibody fragment, protein complex, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68619.67

構造登録者

Sillen, M.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J. (登録日: 2018-06-25, 公開日: 2020-01-01, 最終更新日: 2024-01-17)

• 主引用文献: Sillen, M.,Weeks, S.D.,Zhou, X.,Komissarov, A.A.,Florova, G.,Idell, S.,Strelkov, S.V.,Declerck, P.J.; Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.; J.Thromb.Haemost., 18:681-692, 2020; PubMed: 31858714; DOI: 10.1111/jth.14716

実験手法

X-RAY DIFFRACTION (2.03 Å)