6GVX

Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C)

Summary for 6GVX

Entry DOI	10.2210/pdb6gvx/pdb
Descriptor	Maternal embryonic leucine zipper kinase, 1,2-ETHANEDIOL, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, ... (4 entities in total)
Functional Keywords	dorsomorphin, melk, inhibitor, cancer, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	80369.31
Authors	Golik, P.,Rembacz, K.P.,Zrubek, K.,Romanowska, M.,Bugusz, J.,Wladyka, B.,Dubin, G. (deposition date: 2018-06-21, release date: 2019-05-29, Last modification date: 2024-01-17)
Primary citation	Rembacz, K.P.,Zrubek, K.M.,Golik, P.,Michalik, K.,Bogusz, J.,Wladyka, B.,Romanowska, M.,Dubin, G. Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C). Arch.Biochem.Biophys., 671:1-7, 2019 Cited by PubMed: 31108049 DOI: 10.1016/j.abb.2019.05.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation