6GVX

Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C)

6GVX の概要

• エントリーDOI: 10.2210/pdb6gvx/pdb
• 分子名称: Maternal embryonic leucine zipper kinase, 1,2-ETHANEDIOL, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, ... (4 entities in total)
• 機能のキーワード: dorsomorphin, melk, inhibitor, cancer, oncoprotein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80369.31

構造登録者

Golik, P.,Rembacz, K.P.,Zrubek, K.,Romanowska, M.,Bugusz, J.,Wladyka, B.,Dubin, G. (登録日: 2018-06-21, 公開日: 2019-05-29, 最終更新日: 2024-01-17)

• 主引用文献: Rembacz, K.P.,Zrubek, K.M.,Golik, P.,Michalik, K.,Bogusz, J.,Wladyka, B.,Romanowska, M.,Dubin, G.; Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C).; Arch.Biochem.Biophys., 671:1-7, 2019; PubMed: 31108049; DOI: 10.1016/j.abb.2019.05.014

実験手法

X-RAY DIFFRACTION (2.24 Å)