6GVJ

Human Mps1 kinase domain with ordered activation loop

Summary for 6GVJ

Entry DOI	10.2210/pdb6gvj/pdb
Descriptor	Dual specificity protein kinase TTK, GLYCEROL, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	mps1, ttk, kinase, mitosis checkpoint, transferase, activation loop, activation segment
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	49496.04
Authors	Roorda, J.C.,Hiruma, Y.,Joosten, R.P.,Perrakis, A. (deposition date: 2018-06-21, release date: 2019-01-09, Last modification date: 2024-01-17)
Primary citation	Roorda, J.C.,Joosten, R.P.,Perrakis, A.,Hiruma, Y. A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop. Proteins, 87:348-352, 2019 Cited by PubMed: 30582207 DOI: 10.1002/prot.25651 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation