6GS6
Cyclophilin A single mutant D66A in complex with an inhibitor.
Summary for 6GS6
Entry DOI | 10.2210/pdb6gs6/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase A, ethyl N-[(4-aminobenzyl)carbamoyl]glycinate, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | cyclophilins, cypa, cypa mutant, inhibitor, ppiase, complex, isomerase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18321.91 |
Authors | Georgiou, C.,De Simone, A.,Juarez-Jimenez, J.,Walkinshaw, M.D.,Michel, J. (deposition date: 2018-06-13, release date: 2019-06-26, Last modification date: 2024-01-17) |
Primary citation | Juarez-Jimenez, J.,Gupta, A.A.,Karunanithy, G.,May, A.,Georgiou, C.,Ioannidis, H.,De Simone, A.,Barlow, P.N.,Hulme, A.N.,Walkinshaw, M.D.,Baldwin, A.,Michel, J. Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A Chem Sci, 2020 Cited by DOI: 10.1039/C9SC04696HPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.16 Å) |
Structure validation
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