6GS6

Cyclophilin A single mutant D66A in complex with an inhibitor.

6GS6 の概要

• エントリーDOI: 10.2210/pdb6gs6/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase A, ethyl N-[(4-aminobenzyl)carbamoyl]glycinate, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: cyclophilins, cypa, cypa mutant, inhibitor, ppiase, complex, isomerase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18321.91

構造登録者

Georgiou, C.,De Simone, A.,Juarez-Jimenez, J.,Walkinshaw, M.D.,Michel, J. (登録日: 2018-06-13, 公開日: 2019-06-26, 最終更新日: 2024-01-17)

• 主引用文献: Juarez-Jimenez, J.,Gupta, A.A.,Karunanithy, G.,May, A.,Georgiou, C.,Ioannidis, H.,De Simone, A.,Barlow, P.N.,Hulme, A.N.,Walkinshaw, M.D.,Baldwin, A.,Michel, J.; Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A; Chem Sci, 2020; DOI: 10.1039/C9SC04696H

実験手法

X-RAY DIFFRACTION (1.16 Å)