6GOU

Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I

Summary for 6GOU

Entry DOI	10.2210/pdb6gou/pdb
Related	5ADZ
Descriptor	Alkyldihydroxyacetonephosphate synthase, peroxisomal, FLAVIN-ADENINE DINUCLEOTIDE, (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide (3 entities in total)
Functional Keywords	ether phospholipids, catalytic mechanism, inhibitor, anti-cancer, flavoprotein
Biological source	Cavia porcellus (Guinea pig)
Total number of polymer chains	4
Total formula weight	295933.01
Authors	Mattevi, A.,Piano, V. (deposition date: 2018-06-04, release date: 2019-01-02, Last modification date: 2024-01-17)
Primary citation	Stazi, G.,Battistelli, C.,Piano, V.,Mazzone, R.,Marrocco, B.,Marchese, S.,Louie, S.M.,Zwergel, C.,Antonini, L.,Patsilinakos, A.,Ragno, R.,Viviano, M.,Sbardella, G.,Ciogli, A.,Fabrizi, G.,Cirilli, R.,Strippoli, R.,Marchetti, A.,Tripodi, M.,Nomura, D.K.,Mattevi, A.,Mai, A.,Valente, S. Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. Eur J Med Chem, 163:722-735, 2018 Cited by PubMed: 30576903 DOI: 10.1016/j.ejmech.2018.11.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation