6GNV
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a isopropyl methyl indole aryl sulphonamide ligand
Summary for 6GNV
Entry DOI | 10.2210/pdb6gnv/pdb |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, ~{N}-[2-methyl-5-(2-methylpropyl)indazol-4-yl]-4-[4-(1-methylpiperidin-4-yl)butyl]benzenesulfonamide, ... (5 entities in total) |
Functional Keywords | acyltransferase, transferase, drug discovery |
Biological source | Leishmania major |
Total number of polymer chains | 1 |
Total formula weight | 48830.54 |
Authors | Robinson, D.A.,Harrison, J.R.,Brand, S.,Smith, V.C.,Thompson, S.,Smith, A.,Davies, K.,Mok, N.Y.,Torrie, L.S.,Collie, I.,Hallyburton, I.,Norval, S.,Simeons, F.R.C.,Stojanovski, L.,Frearson, J.A.,Brenk, R.,Wyatt, P.G.,Gilbert, I.H.,Read, K.D. (deposition date: 2018-05-31, release date: 2018-10-10, Last modification date: 2024-01-17) |
Primary citation | Harrison, J.R.,Brand, S.,Smith, V.,Robinson, D.A.,Thompson, S.,Smith, A.,Davies, K.,Mok, N.,Torrie, L.S.,Collie, I.,Hallyburton, I.,Norval, S.,Simeons, F.R.C.,Stojanovski, L.,Frearson, J.A.,Brenk, R.,Wyatt, P.G.,Gilbert, I.H.,Read, K.D. A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors. J. Med. Chem., 61:8374-8389, 2018 Cited by PubMed: 30207721DOI: 10.1021/acs.jmedchem.8b00884 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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