6GN1

Crystal Structure of Glycogen synthase kinase-3 beta (GSK3B) in Complex with PIK-75

6GN1 の概要

• エントリーDOI: 10.2210/pdb6gn1/pdb
• 分子名称: Glycogen synthase kinase-3 beta, CHLORIDE ION, ~{N}-[(~{E})-(6-bromanylimidazo[1,2-a]pyridin-3-yl)methylideneamino]-~{N},2-dimethyl-5-nitro-benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: glycogen synthase kinase-3 beta, pik-75, halogen bond, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84316.83

構造登録者

Tesch, R.,Becker, C.,Mueller, M.P.,Sant'Anna, C.M.R.,Fraga, C.A.M.,Rauh, D. (登録日: 2018-05-29, 公開日: 2018-06-20, 最終更新日: 2024-01-17)

• 主引用文献: Tesch, R.,Becker, C.,Muller, M.P.,Beck, M.E.,Quambusch, L.,Getlik, M.,Lategahn, J.,Uhlenbrock, N.,Costa, F.N.,Poleto, M.D.,Pinheiro, P.S.M.,Rodrigues, D.A.,Sant'Anna, C.M.R.,Ferreira, F.F.,Verli, H.,Fraga, C.A.M.,Rauh, D.; An Unusual Intramolecular Halogen Bond Guides Conformational Selection.; Angew. Chem. Int. Ed. Engl., 57:9970-9975, 2018; PubMed: 29873877; DOI: 10.1002/anie.201804917

実験手法

X-RAY DIFFRACTION (2.6 Å)