6GMU

Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations

Summary for 6GMU

Entry DOI	10.2210/pdb6gmu/pdb
Descriptor	Serum Paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	beta-propeller, lactonase, hdl, organophosphate-hydrolase, hydrolase
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	39961.62
Authors	Ben-David, M.,Sussman, J.L.,Tawfik, D.S. (deposition date: 2018-05-28, release date: 2019-04-17, Last modification date: 2024-01-17)
Primary citation	Ben-David, M.,Soskine, M.,Dubovetskyi, A.,Cherukuri, K.P.,Dym, O.,Sussman, J.L.,Liao, Q.,Szeler, K.,Kamerlin, S.C.L.,Tawfik, D.S. Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition. Mol.Biol.Evol., 37:1133-1147, 2020 Cited by PubMed: 31873734 DOI: 10.1093/molbev/msz298 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation