6GKL

Translation initiation factor 4E in complex with beta-phosphorothioate trinucleotide mRNA 5' cap diastereomer 2 (m7GppSpApG D2)

Summary for 6GKL

• Entry DOI: 10.2210/pdb6gkl/pdb
• Related: 5M7V 5M7W 5M7X 5M7Z 5M80 5M81 5M83 5M84
• Descriptor: Eukaryotic translation initiation factor 4E, [[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-4,5-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: protein-ligand complex, translation, translation initiation factor, eif4e, mrna 5' cap, m7gppspapg, phosphorothioate, thiophosphate
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 4
• Total formula weight: 93307.58

Authors

Warminski, M.,Nowak, E.,Kowalska, J.,Jemielity, J.,Nowotny, M. (deposition date: 2018-05-21, release date: 2019-06-19, Last modification date: 2024-01-17)

• Primary citation: Warminski, M.,Nowak, E.,Kubacka, D.,Kowalska, J.,Nowotny, M.,Jemielity, J.; Translation initiation factor 4E in complex with beta-phosphorothioate trinucleotide mRNA 5' cap diastereomer 2 (m7GppSpApG D2); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)