6GKL

Translation initiation factor 4E in complex with beta-phosphorothioate trinucleotide mRNA 5' cap diastereomer 2 (m7GppSpApG D2)

6GKL の概要

• エントリーDOI: 10.2210/pdb6gkl/pdb
• 関連するPDBエントリー: 5M7V 5M7W 5M7X 5M7Z 5M80 5M81 5M83 5M84
• 分子名称: Eukaryotic translation initiation factor 4E, [[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-4,5-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, translation, translation initiation factor, eif4e, mrna 5' cap, m7gppspapg, phosphorothioate, thiophosphate
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 93307.58

構造登録者

Warminski, M.,Nowak, E.,Kowalska, J.,Jemielity, J.,Nowotny, M. (登録日: 2018-05-21, 公開日: 2019-06-19, 最終更新日: 2024-01-17)

• 主引用文献: Warminski, M.,Nowak, E.,Kubacka, D.,Kowalska, J.,Nowotny, M.,Jemielity, J.; Translation initiation factor 4E in complex with beta-phosphorothioate trinucleotide mRNA 5' cap diastereomer 2 (m7GppSpApG D2); To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)