6GJ8
CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852
Summary for 6GJ8
Entry DOI | 10.2210/pdb6gj8/pdb |
Descriptor | GTPase KRas, (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kras 4b, k-ras 2, ki-ras, c-k-ras, c-ki-ras, gtpase kras, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20319.77 |
Authors | Kessler, D.,Mcconnell, D.M.,Mantoulidis, A. (deposition date: 2018-05-16, release date: 2019-07-31, Last modification date: 2024-01-17) |
Primary citation | Kessler, D.,Gmachl, M.,Mantoulidis, A.,Martin, L.J.,Zoephel, A.,Mayer, M.,Gollner, A.,Covini, D.,Fischer, S.,Gerstberger, T.,Gmaschitz, T.,Goodwin, C.,Greb, P.,Haring, D.,Hela, W.,Hoffmann, J.,Karolyi-Oezguer, J.,Knesl, P.,Kornigg, S.,Koegl, M.,Kousek, R.,Lamarre, L.,Moser, F.,Munico-Martinez, S.,Peinsipp, C.,Phan, J.,Rinnenthal, J.,Sai, J.,Salamon, C.,Scherbantin, Y.,Schipany, K.,Schnitzer, R.,Schrenk, A.,Sharps, B.,Siszler, G.,Sun, Q.,Waterson, A.,Wolkerstorfer, B.,Zeeb, M.,Pearson, M.,Fesik, S.W.,McConnell, D.B. Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116:15823-15829, 2019 Cited by PubMed: 31332011DOI: 10.1073/pnas.1904529116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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