6GJ8

CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852

6GJ8 の概要

• エントリーDOI: 10.2210/pdb6gj8/pdb
• 分子名称: GTPase KRas, (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: kras 4b, k-ras 2, ki-ras, c-k-ras, c-ki-ras, gtpase kras, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20319.77

構造登録者

Kessler, D.,Mcconnell, D.M.,Mantoulidis, A. (登録日: 2018-05-16, 公開日: 2019-07-31, 最終更新日: 2024-01-17)

• 主引用文献: Kessler, D.,Gmachl, M.,Mantoulidis, A.,Martin, L.J.,Zoephel, A.,Mayer, M.,Gollner, A.,Covini, D.,Fischer, S.,Gerstberger, T.,Gmaschitz, T.,Goodwin, C.,Greb, P.,Haring, D.,Hela, W.,Hoffmann, J.,Karolyi-Oezguer, J.,Knesl, P.,Kornigg, S.,Koegl, M.,Kousek, R.,Lamarre, L.,Moser, F.,Munico-Martinez, S.,Peinsipp, C.,Phan, J.,Rinnenthal, J.,Sai, J.,Salamon, C.,Scherbantin, Y.,Schipany, K.,Schnitzer, R.,Schrenk, A.,Sharps, B.,Siszler, G.,Sun, Q.,Waterson, A.,Wolkerstorfer, B.,Zeeb, M.,Pearson, M.,Fesik, S.W.,McConnell, D.B.; Drugging an undruggable pocket on KRAS.; Proc.Natl.Acad.Sci.USA, 116:15823-15829, 2019; PubMed: 31332011; DOI: 10.1073/pnas.1904529116

実験手法

X-RAY DIFFRACTION (1.65 Å)