6GJ4

Tubulin-6j complex

6GJ4 の概要

• エントリーDOI: 10.2210/pdb6gj4/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265303.10

構造登録者

Brindisi, M.,Ulivieri, C.,Alfano, G.,Gemma, S.,Balaguer, F.d.A.,Khan, T.,Grillo, A.,Chemi, G.,Menchon, G.,Prota, A.E.,Olieric, N.,Agell, D.L.,Barasoain, I.,Diaz, J.F.,Nebbioso, A.,Conte, M.R.,Lopresti, L.,Magnano, S.,Amet, R.,Kinsella, P.,Zisterer, D.M.,Ibrahim, O.,O'Sullivan, J.,Morbidelli, L.,Spaccapelo, R.,Baldari, C.,Butini, S.,Novellino, E.,Campiani, G.,Altucci, L.,Steinmetz, M.O.,Brogi, S. (登録日: 2018-05-16, 公開日: 2018-12-05, 最終更新日: 2024-01-17)

• 主引用文献: Brindisi, M.,Ulivieri, C.,Alfano, G.,Gemma, S.,de Asis Balaguer, F.,Khan, T.,Grillo, A.,Chemi, G.,Menchon, G.,Prota, A.E.,Olieric, N.,Lucena-Agell, D.,Barasoain, I.,Diaz, J.F.,Nebbioso, A.,Conte, M.,Lopresti, L.,Magnano, S.,Amet, R.,Kinsella, P.,Zisterer, D.M.,Ibrahim, O.,O'Sullivan, J.,Morbidelli, L.,Spaccapelo, R.,Baldari, C.,Butini, S.,Novellino, E.,Campiani, G.,Altucci, L.,Steinmetz, M.O.,Brogi, S.; Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.; Eur J Med Chem, 162:290-320, 2018; PubMed: 30448418; DOI: 10.1016/j.ejmech.2018.11.004

実験手法

X-RAY DIFFRACTION (2.4 Å)