6GGB

p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9318

Summary for 6GGB

DescriptorCellular tumor antigen p53, ZINC ION, [9-ethyl-7-(4-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium, ... (7 entities in total)
Functional Keywordsp53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight50255.88
Authors
Joerger, A.C.,Bauer, M.R. (deposition date: 2018-05-03, release date: 2019-05-22)
Primary citation
Jones, R.N.,Bauer, M.R.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J.
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C
to be published,
Experimental method
X-RAY DIFFRACTION (1.32 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.16130 0.6% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6ggb
no rotation
Molmil generated image of 6ggb
rotated about x axis by 90°
Molmil generated image of 6ggb
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6ggb
no rotation
Molmil generated image of 6ggb
rotated about x axis by 90°
Molmil generated image of 6ggb
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6ggb.pdb2.gz [72.47 KB])
Coordinate files for Biological unit (6ggb.pdb1.gz [72.46 KB])