6GGB
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9318
6GGB の概要
エントリーDOI | 10.2210/pdb6ggb/pdb |
分子名称 | Cellular tumor antigen p53, ZINC ION, [9-ethyl-7-(4-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium, ... (7 entities in total) |
機能のキーワード | p53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 50255.88 |
構造登録者 | |
主引用文献 | Bauer, M.R.,Jones, R.N.,Tareque, R.K.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J. A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. Future Med Chem, 11:2491-2504, 2019 Cited by PubMed: 31633398DOI: 10.4155/fmc-2019-0181 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.32 Å) |
構造検証レポート
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