6GGA

p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9284

6GGA の概要

• エントリーDOI: 10.2210/pdb6gga/pdb
• 分子名称: Cellular tumor antigen p53, (7-bromanyl-9-ethyl-carbazol-3-yl)methyl-methyl-azanium, ZINC ION, ... (4 entities in total)
• 機能のキーワード: p53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49828.90

構造登録者

Joerger, A.C.,Bauer, M.R. (登録日: 2018-05-03, 公開日: 2019-05-22, 最終更新日: 2024-01-17)

• 主引用文献: Bauer, M.R.,Jones, R.N.,Tareque, R.K.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J.; A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.; Future Med Chem, 11:2491-2504, 2019; PubMed: 31633398; DOI: 10.4155/fmc-2019-0181

実験手法

X-RAY DIFFRACTION (1.55000123008 Å)