6GFZ

pVHL:EloB:EloC in complex with modified VH032 containing (3S,4S)-3-fluoro-4-hydroxyproline (ligand 14b)

6GFZ の概要

• エントリーDOI: 10.2210/pdb6gfz/pdb
• 分子名称: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
• 機能のキーワード: protein complex, ubiquitin ligase, hypoxia inducible factor, fluorinated hydroxyproline, ligase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 168911.41

構造登録者

Gadd, M.S.,Testa, A.,Ciulli, A. (登録日: 2018-05-02, 公開日: 2018-07-11, 最終更新日: 2024-01-17)

• 主引用文献: Testa, A.,Lucas, X.,Castro, G.V.,Chan, K.H.,Wright, J.E.,Runcie, A.C.,Gadd, M.S.,Harrison, W.T.A.,Ko, E.J.,Fletcher, D.,Ciulli, A.; 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation.; J. Am. Chem. Soc., 140:9299-9313, 2018; PubMed: 29949369; DOI: 10.1021/jacs.8b05807

実験手法

X-RAY DIFFRACTION (2.3 Å)