6GEY

Trypanosoma brucei PTR1 in complex with inhibitor 4g (F125)

6GEY の概要

• エントリーDOI: 10.2210/pdb6gey/pdb
• 関連するPDBエントリー: 6GCK 6GCL 6GCP 6GCQ 6GD0 6GD4 6GDO 6GDP 6GEX
• 分子名称: Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-azanyl-~{N}-[(3,4-dichlorophenyl)methyl]-1,3-benzothiazole-6-carboxamide, ... (6 entities in total)
• 機能のキーワード: trypanosoma brucei, pteridine reductase, ptr1, tbptr1, benzothiazole, oxidoreductase
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127355.18

構造登録者

Landi, G.,Pozzi, C.,Mangani, S. (登録日: 2018-04-27, 公開日: 2019-04-03, 最終更新日: 2024-01-17)

• 主引用文献: Linciano, P.,Pozzi, C.,Iacono, L.D.,di Pisa, F.,Landi, G.,Bonucci, A.,Gul, S.,Kuzikov, M.,Ellinger, B.,Witt, G.,Santarem, N.,Baptista, C.,Franco, C.,Moraes, C.B.,Muller, W.,Wittig, U.,Luciani, R.,Sesenna, A.,Quotadamo, A.,Ferrari, S.,Pohner, I.,Cordeiro-da-Silva, A.,Mangani, S.,Costantino, L.,Costi, M.P.; Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.; J.Med.Chem., 62:3989-4012, 2019; PubMed: 30908048; DOI: 10.1021/acs.jmedchem.8b02021

実験手法

X-RAY DIFFRACTION (1.56 Å)