6G9S
Structural basis for the inhibition of E. coli PBP2
Summary for 6G9S
Entry DOI | 10.2210/pdb6g9s/pdb |
Related | 6G9F 6G9P |
Descriptor | Peptidoglycan D,D-transpeptidase MrdA, (3~{R},6~{S})-6-(aminomethyl)-4-(1,3-oxazol-5-yl)-3-(sulfooxyamino)-3,6-dihydro-2~{H}-pyridine-1-carboxylic acid (3 entities in total) |
Functional Keywords | penicillin binding protein, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Escherichia coli K-12 |
Total number of polymer chains | 1 |
Total formula weight | 65409.83 |
Authors | |
Primary citation | Levy, N.,Bruneau, J.M.,Le Rouzic, E.,Bonnard, D.,Le Strat, F.,Caravano, A.,Chevreuil, F.,Barbion, J.,Chasset, S.,Ledoussal, B.,Moreau, F.,Ruff, M. Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62:4742-4754, 2019 Cited by PubMed: 30995398DOI: 10.1021/acs.jmedchem.9b00338 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.001 Å) |
Structure validation
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