6G98

Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide

6G98 の概要

• エントリーDOI: 10.2210/pdb6g98/pdb
• 分子名称: Carbonic anhydrase 9, ZINC ION, 4-[2-[3-(cyclododecylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic acid, ... (4 entities in total)
• 機能のキーワード: lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 115243.18

構造登録者

Leitans, J.,Tars, K. (登録日: 2018-04-10, 公開日: 2018-07-04, 最終更新日: 2024-01-17)

• 主引用文献: Kazokaite, J.,Niemans, R.,Dudutiene, V.,Becker, H.M.,Leitans, J.,Zubriene, A.,Baranauskiene, L.,Gondi, G.,Zeidler, R.,Matuliene, J.,Tars, K.,Yaromina, A.,Lambin, P.,Dubois, L.J.,Matulis, D.; Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells.; Oncotarget, 9:26800-26816, 2018; PubMed: 29928486; DOI: 10.18632/oncotarget.25508

実験手法

X-RAY DIFFRACTION (2.47 Å)