6G8N

Yeast 20S proteasome in complex with Cystargolide B Derivative 2

6G8N の概要

• エントリーDOI: 10.2210/pdb6g8n/pdb
• 分子名称: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total)
• 機能のキーワード: proteasome, inhibitor, beta lactone; natural product derivative, binding analysis, hydrolase
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 734187.58

構造登録者

Groll, M.,Tello-Aburto, R. (登録日: 2018-04-09, 公開日: 2018-09-12, 最終更新日: 2024-01-17)

• 主引用文献: Niroula, D.,Hallada, L.P.,Le Chapelain, C.,Ganegamage, S.K.,Dotson, D.,Rogelj, S.,Groll, M.,Tello-Aburto, R.; Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors.; Eur J Med Chem, 157:962-977, 2018; PubMed: 30165344; DOI: 10.1016/j.ejmech.2018.08.052

実験手法

X-RAY DIFFRACTION (3 Å)