6G88

Crystal structure of Enterococcus Faecium D63r Penicillin-Binding protein 5 (PBP5fm)

6G88 の概要

• エントリーDOI: 10.2210/pdb6g88/pdb
• 関連するPDBエントリー: 6G0K
• 分子名称: Low affinity penicillin-binding protein 5 (PBP5), (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, SULFATE ION (3 entities in total)
• 機能のキーワード: penicillin-binding, ceftobiprole, enterococcus faecium, antibiotic resistance, antibiotic
• 由来する生物種: Enterococcus faecium (Streptococcus faecium)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 214129.26

構造登録者

Sauvage, E.,El Gachi, M.,Herman, R.,Kerff, F.,Charlier, P. (登録日: 2018-04-08, 公開日: 2019-04-24)

• 主引用文献: Sauvage, E.,El Gachi, M.,Kerff, F.,Herman, R.,Verlaine, O.,Amoroso, A.,Page, M.G.P.,Joris, B.,Charlier, P.; Structural basis of inactivation of Enterococcus faecium penicillin binding protein 5 by ceftobiprole.; To Be Published,

実験手法

X-RAY DIFFRACTION (3.3 Å)