6G5X
Crystal Structure of KDM4A with compound YP-02-145
Summary for 6G5X
Entry DOI | 10.2210/pdb6g5x/pdb |
Descriptor | Lysine-specific demethylase 4A, ZINC ION, NICKEL (II) ION, ... (8 entities in total) |
Functional Keywords | kdm4a, ligand binding, drug design, inhibitor design, cancer, epigenetics, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 85151.74 |
Authors | Malecki, P.H.,Carter, D.M.,Gohlke, U.,Specker, E.,Nazare, M.,Weiss, M.S.,Heinemann, U. (deposition date: 2018-03-30, release date: 2019-04-10, Last modification date: 2024-01-31) |
Primary citation | Carter, D.M.,Specker, E.,Malecki, P.H.,Przygodda, J.,Dudaniec, K.,Weiss, M.S.,Heinemann, U.,Nazare, M.,Gohlke, U. Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J.Med.Chem., 64:14266-14282, 2021 Cited by PubMed: 34555281DOI: 10.1021/acs.jmedchem.1c00693 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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