6G5X

Crystal Structure of KDM4A with compound YP-02-145

Summary for 6G5X

• Entry DOI: 10.2210/pdb6g5x/pdb
• Descriptor: Lysine-specific demethylase 4A, ZINC ION, NICKEL (II) ION, ... (8 entities in total)
• Functional Keywords: kdm4a, ligand binding, drug design, inhibitor design, cancer, epigenetics, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 85151.74

Authors

Malecki, P.H.,Carter, D.M.,Gohlke, U.,Specker, E.,Nazare, M.,Weiss, M.S.,Heinemann, U. (deposition date: 2018-03-30, release date: 2019-04-10, Last modification date: 2024-01-31)

• Primary citation: Carter, D.M.,Specker, E.,Malecki, P.H.,Przygodda, J.,Dudaniec, K.,Weiss, M.S.,Heinemann, U.,Nazare, M.,Gohlke, U.; Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer.; J.Med.Chem., 64:14266-14282, 2021; PubMed: 34555281; DOI: 10.1021/acs.jmedchem.1c00693

Experimental method

X-RAY DIFFRACTION (1.78 Å)