6G5W

Crystal Structure of KDM4A with compound YP-03-038

6G5W の概要

• エントリーDOI: 10.2210/pdb6g5w/pdb
• 分子名称: Lysine-specific demethylase 4A, ZINC ION, NICKEL (II) ION, ... (8 entities in total)
• 機能のキーワード: kdm4a, ligand binding, drug design, inhibitor design, cancer, epigenetics, jmjd2a, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84939.54

構造登録者

Malecki, P.H.,Carter, D.M.,Gohlke, U.,Specker, E.,Nazare, M.,Weiss, M.S.,Heinemann, U. (登録日: 2018-03-30, 公開日: 2019-04-10, 最終更新日: 2024-01-31)

• 主引用文献: Carter, D.M.,Specker, E.,Malecki, P.H.,Przygodda, J.,Dudaniec, K.,Weiss, M.S.,Heinemann, U.,Nazare, M.,Gohlke, U.; Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer.; J.Med.Chem., 64:14266-14282, 2021; PubMed: 34555281; DOI: 10.1021/acs.jmedchem.1c00693

実験手法

X-RAY DIFFRACTION (1.83 Å)