6G5P

Crystal structure of human SP100 in complex with bromodomain-focused fragment FM009493b 2,3-Dimethoxy-2,3-dimethyl-2,3-dihydro-1,4-benzodioxin-6-amine

6G5P の概要

• エントリーDOI: 10.2210/pdb6g5p/pdb
• 関連するPDBエントリー: 5PWC
• 分子名称: Nuclear autoantigen Sp-100, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
• 機能のキーワード: fragment screening, epigenetics, bromodomain, structural genomics consortium, sgc, xchem, diamond i04-1, pandda, xchemexplorer, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus. Isoform Sp100-C: Nucleus : P23497
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43976.99

構造登録者

Talon, R.P.H.,Krojer, T.,Tallant, C.,Nunez-Alonso, G.,Fairhead, M.,Szykowska, A.,Collins, P.,Pearce, N.M.,Ng, J.,MacLean, E.,Wright, N.,Douangamath, A.,Brandao-Neto, J.,Burgess-Brown, N.,Huber, K.,Knapp, S.,Brennan, P.E.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F. (登録日: 2018-03-29, 公開日: 2018-04-11, 最終更新日: 2024-05-01)

• 主引用文献: Talon, R.P.H.,Bowkett, D.,Tallant, C.,Schofield, C.,von Delft, F.,Knapp, S.,Bruton, G.,Brennan, P.E.; Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces; Biorxiv, 2018; DOI: 10.1101/283069

実験手法

X-RAY DIFFRACTION (1.35 Å)