6G5N

Crystal structure of human SP100 in complex with bromodomain-focused fragment XS039818e 1-(3-Phenyl-1,2,4-oxadiazol-5-yl)methanamine

Summary for 6G5N

• Entry DOI: 10.2210/pdb6g5n/pdb
• Related: 5PWC
• Descriptor: Nuclear autoantigen Sp-100, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
• Functional Keywords: fragment screening, epigenetics, bromodomain, structural genomics consortium, sgc, xchem, diamond i04-1, pandda, xchemexplorer, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus. Isoform Sp100-C: Nucleus : P23497
• Total number of polymer chains: 2
• Total formula weight: 43912.91

Authors

Talon, R.P.H.,Krojer, T.,Tallant, C.,Nunez-Alonso, G.,Fairhead, M.,Szykowska, A.,Collins, P.,Pearce, N.M.,Ng, J.,MacLean, E.,Wright, N.,Douangamath, A.,Brandao-Neto, J.,Burgess-Brown, N.,Huber, K.,Knapp, S.,Brennan, P.E.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F. (deposition date: 2018-03-29, release date: 2018-04-11)

• Primary citation: Talon, R.P.H.,Bowkett, D.,Tallant, C.,Schofield, C.,von Delft, F.,Knapp, S.,Bruton, G.,Brennan, P.E.; Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces; Biorxiv, 2018; DOI: 10.1101/283069

Experimental method

X-RAY DIFFRACTION (1.765 Å)