6G5F

Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1

Summary for 6G5F

Entry DOI	10.2210/pdb6g5f/pdb
Descriptor	Botulinum neurotoxin type B, Synaptotagmin-1, GLYCEROL, ... (5 entities in total)
Functional Keywords	botulinum toxin, neurotoxin, protein engineering, receptor binding, toxin
Biological source	Clostridium botulinum More
Total number of polymer chains	3
Total formula weight	304983.75
Authors	Masuyer, G.,Elliot, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Beard, M.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Dong, M.,Krupp, J.,Stenmark, P. (deposition date: 2018-03-29, release date: 2019-01-16, Last modification date: 2024-01-31)
Primary citation	Elliott, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Masuyer, G.,Beard, M.,Boone, C.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Zhang, S.,Dong, M.,Stenmark, P.,Krupp, J. Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Sci Adv, 5:eaau7196-eaau7196, 2019 Cited by PubMed: 30746458 DOI: 10.1126/sciadv.aau7196 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation