6G54

Crystal structure of ERK2 covalently bound to SM1-71

Summary for 6G54

Entry DOI	10.2210/pdb6g54/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide, ... (6 entities in total)
Functional Keywords	kinase, covalent inhibitor, mapk, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43032.17
Authors	Chaikuad, A.,Suman, R.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gray, N.S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-03-29, release date: 2019-02-27, Last modification date: 2024-01-17)
Primary citation	Rao, S.,Gurbani, D.,Du, G.,Everley, R.A.,Browne, C.M.,Chaikuad, A.,Tan, L.,Schroder, M.,Gondi, S.,Ficarro, S.B.,Sim, T.,Kim, N.D.,Berberich, M.J.,Knapp, S.,Marto, J.A.,Westover, K.D.,Sorger, P.K.,Gray, N.S. Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol, 26:818-, 2019 Cited by PubMed: 30982749 DOI: 10.1016/j.chembiol.2019.02.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation