6G4Z
Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 2f
Summary for 6G4Z
Entry DOI | 10.2210/pdb6g4z/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase 14, 5-fluoranyl-1-[4-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrol-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide (3 entities in total) |
Functional Keywords | protein serine/threonine kinase, nf-kappab, map3k14, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 2 |
Total formula weight | 77869.61 |
Authors | Leonardo-Silvestre, H.,McEwan, P.A.,Hymowitz, S.G. (deposition date: 2018-03-28, release date: 2018-07-04, Last modification date: 2024-01-17) |
Primary citation | Blaquiere, N.,Castanedo, G.M.,Burch, J.D.,Berezhkovskiy, L.M.,Brightbill, H.,Brown, S.,Chan, C.,Chiang, P.C.,Crawford, J.J.,Dong, T.,Fan, P.,Feng, J.,Ghilardi, N.,Godemann, R.,Gogol, E.,Grabbe, A.,Hole, A.J.,Hu, B.,Hymowitz, S.G.,Alaoui Ismaili, M.H.,Le, H.,Lee, P.,Lee, W.,Lin, X.,Liu, N.,McEwan, P.A.,McKenzie, B.,Silvestre, H.L.,Suto, E.,Sujatha-Bhaskar, S.,Wu, G.,Wu, L.C.,Zhang, Y.,Zhong, Z.,Staben, S.T. Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. J. Med. Chem., 61:6801-6813, 2018 Cited by PubMed: 29940120DOI: 10.1021/acs.jmedchem.8b00678 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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