6G4Y
Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 1a
6G4Y の概要
エントリーDOI | 10.2210/pdb6g4y/pdb |
分子名称 | Mitogen-activated protein kinase kinase kinase 14, SULFATE ION, 10-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrolidin-3-yl]ethynyl]-~{N}3-(oxan-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide, ... (4 entities in total) |
機能のキーワード | protein serine/threonine kinase, nf-kappab, map3k14, transferase |
由来する生物種 | Mus musculus (House Mouse) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 78458.17 |
構造登録者 | |
主引用文献 | Blaquiere, N.,Castanedo, G.M.,Burch, J.D.,Berezhkovskiy, L.M.,Brightbill, H.,Brown, S.,Chan, C.,Chiang, P.C.,Crawford, J.J.,Dong, T.,Fan, P.,Feng, J.,Ghilardi, N.,Godemann, R.,Gogol, E.,Grabbe, A.,Hole, A.J.,Hu, B.,Hymowitz, S.G.,Alaoui Ismaili, M.H.,Le, H.,Lee, P.,Lee, W.,Lin, X.,Liu, N.,McEwan, P.A.,McKenzie, B.,Silvestre, H.L.,Suto, E.,Sujatha-Bhaskar, S.,Wu, G.,Wu, L.C.,Zhang, Y.,Zhong, Z.,Staben, S.T. Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. J. Med. Chem., 61:6801-6813, 2018 Cited by PubMed: 29940120DOI: 10.1021/acs.jmedchem.8b00678 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.65 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード