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6G4Y

Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 1a

6G4Y の概要
エントリーDOI10.2210/pdb6g4y/pdb
分子名称Mitogen-activated protein kinase kinase kinase 14, SULFATE ION, 10-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrolidin-3-yl]ethynyl]-~{N}3-(oxan-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide, ... (4 entities in total)
機能のキーワードprotein serine/threonine kinase, nf-kappab, map3k14, transferase
由来する生物種Mus musculus (House Mouse)
タンパク質・核酸の鎖数2
化学式量合計78458.17
構造登録者
Hole, A.J.,Hymowitz, S.G.,McEwan, P.A. (登録日: 2018-03-28, 公開日: 2018-07-04, 最終更新日: 2024-05-08)
主引用文献Blaquiere, N.,Castanedo, G.M.,Burch, J.D.,Berezhkovskiy, L.M.,Brightbill, H.,Brown, S.,Chan, C.,Chiang, P.C.,Crawford, J.J.,Dong, T.,Fan, P.,Feng, J.,Ghilardi, N.,Godemann, R.,Gogol, E.,Grabbe, A.,Hole, A.J.,Hu, B.,Hymowitz, S.G.,Alaoui Ismaili, M.H.,Le, H.,Lee, P.,Lee, W.,Lin, X.,Liu, N.,McEwan, P.A.,McKenzie, B.,Silvestre, H.L.,Suto, E.,Sujatha-Bhaskar, S.,Wu, G.,Wu, L.C.,Zhang, Y.,Zhong, Z.,Staben, S.T.
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase.
J. Med. Chem., 61:6801-6813, 2018
Cited by
PubMed: 29940120
DOI: 10.1021/acs.jmedchem.8b00678
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.65 Å)
構造検証レポート
Validation report summary of 6g4y
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-07-17に公開中

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