6G40

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525

Summary for 6G40

• Entry DOI: 10.2210/pdb6g40/pdb
• Descriptor: N-glycosylase/DNA lyase, ~{N}-(3-methoxy-4-methyl-phenyl)-4-(4-methoxy-2-oxidanylidene-3~{H}-benzimidazol-1-yl)piperidine-1-carboxamide, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: n-glycosylase, dna lyase, dna binding protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 3
• Total formula weight: 109082.34

Authors

Masuyer, G.,Helleday, T.,Stenmark, P. (deposition date: 2018-03-26, release date: 2019-04-10, Last modification date: 2024-02-07)

• Primary citation: Wallner, O.,Cazares-Korner, A.,Scaletti, E.R.,Masuyer, G.,Bekkhus, T.,Visnes, T.,Mamonov, K.,Ortis, F.,Lundback, T.,Volkova, M.,Koolmeister, T.,Wiita, E.,Loseva, O.,Pandey, M.,Homan, E.,Benitez-Buelga, C.,Davies, J.,Scobie, M.,Warpman Berglund, U.,Kalderen, C.,Stenmark, P.,Helleday, T.,Michel, M.; Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.; Chemmedchem, 18:e202200310-e202200310, 2023; PubMed: 36128847; DOI: 10.1002/cmdc.202200310

Experimental method

X-RAY DIFFRACTION (2.49 Å)